SHIFT:

A Brief Overview

Assume responsibility for an on-going, innovative research project as a Postdoctoral Fellow at CHOP. Our postdoc experience will broaden your skillset, scientific background, and research capabilities.

About the Laboratory

A postdoctoral fellow position is available in the laboratory of Dr. Liming Pei at the Center for Mitochondrial and Epigenomic Medicine, and Cardiovascular Research Institute at the Children's Hospital of Philadelphia (CHOP) and University of Pennsylvania (UPenn). Our laboratory uses a range of molecular and cellular biology, mouse genetics, and single-cell multiomics technologies to study cardiovascular and metabolic biology and disease. The candidate will work closely with the other members of the research team. Our recent publications include:

Zhao, J., and Pei, L (2020). Cardiac Endocrinology: Heart-Derived Hormones in Physiology and Disease. JACC Basic Transl Sci 5, 949-960. PMID: 33015416. PMCID: PMC7524786.

Pei L, Wallace DC (2018). Mitochondrial Etiology of Neuropsychiatric Disorders. Biological Psychiatry 83, 722-730. PMID: 29290371. PMCID: PMC5891364.
Hu P, Liu J, Zhao J, Wilkins BJ, Lupino K, Wu H, Pei L. (2018). Single-nucleus transcriptomic survey of cell diversity and functional remodeling in the postnatal developing hearts. Genes & Development 32, 1344-1357. PMID: 30254108. PMCID: PMC6169839.

Zhao J, Lupino K, Wilkins BJ, Qiu C, Liu J, Omura Y, Allred AL, McDonald C, Susztak K, Barish GD, Pei L. (2018) Genomic integration of ERR-HNF1 regulates renal bioenergetics and prevents chronic kidney disease. Proceedings of National Academy of Sciences 115, E4910-E4919. PMID: 29735694. PMCID: PMC6003475.

Li J, Liu J, Lupino K, Liu X, Zhang L, Pei L. (2018) GDF15 maturation requires proteolytic cleavage by PCSK3, 5 and 6. Molecular and Cellular Biology. 38 (21). pii: e00249-18. PMID: 30104250. PMCID: PMC6189459.

Wang T, Liu J, McDonald, C, Lupino K, Zhai X, Wilkins BJ, Hakonarson H, Pei L (2017). GDF15 is a heart-derived hormone that regulates body growth. EMBO Molecular Medicine 9, 1150-1164.

Wang T, McDonald C, Petrenko NB, Leblanc M, Giguere V, Evans RM, Patel VV, Pei L (2015). ERRalpha and ERRgamma are essential coordinators of cardiac metabolism and function. Molecular and Cellular Biology 35, 1281-1298.

Pei L*, Mu Y, Leblanc M, Alaynick W, Barish GD, Pankratz M, Tseng TW, Kaufman S, Liddle C, Yu RT, Downes M, Pfaff SL, Auwerx J, Gage FH, Evans RM* (2015).

Dependence of hippocampal function on ERR regulated mitochondrial metabolism. Cell Metabolism 21, 628-636 (* co-corresponding author, featured in cover).

Faculty page: http://www.med.upenn.edu/apps/faculty/index.php/g275/p8651729
Lab website: https://peilab.org
Full publication list:

https://www.ncbi.nlm.nih.gov/myncbi/liming.pei.1/bibliography/public/
CHOP is an equal opportunity employer. Postdoctoral fellows are provided with comprehensive benefits package including eligible health insurance and retirement plan (http://www.research.chop.edu/careers/working-research/benefits-information). CHOP and UPenn offer outstanding research and training environment. The lab is fully committed to the success and career development of every team member. Previous team members are currently working in both academic (universities, hospitals, etc.) and industry (pharmaceutical, biotech, etc.) positions.

CHOP's Commitment to Diversity, Equity, and Inclusion
CHOP is committed to building an inclusive culture where employees feel a sense of belonging, connection, and community within their workplace. We are a team dedicated to fostering an environment that allows for all to be their authentic selves. We are focused on attracting, cultivating, and retaining diverse talent who can help us deliver on our mission to be a world leader in the advancement of healthcare for children.

We strongly encourage all candidates of diverse backgrounds and lived experiences to apply.

Responsibilities

* Participate in project planning, recording, and evaluation of data.

* Conduct independent scholarly research, developing new methods and protocols under the guidance of a mentor (principal investigator).

* Acquire technical, lab management, and grant writing skills.

* Participate in seminars, lectures, poster sessions, national presentations, and professional workshops.

* Supervise junior lab members.

* Assist with other research projects as needed.

Education Qualifications

• Doctorate (required)